Aliases
E7
Antibody Type
Polyclonal Antibody
Species
Human papillomavirus type 18
Uniprot ID
P06788
Immunogen
Recombinant Human papillomavirus type 18 Protein E7 protein (1-105AA)
Raised In
Rabbit
Species Reactivity
Human papillomavirus type 18
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription.
Isotype
IgG
Conjugate
Unconjugated
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Research
Epigenetics and Nuclear Signaling
Literature
[1]”Interactions of SV40 large T antigen and other viral proteins with retinoblastoma tumour suppressor.” Lee C., Cho Y.Rev. Med. Virol. 12:81-92(2002). [2]”Nucleotide sequences of cDNAs for human papillomavirus type 18 transcripts in HeLa cells.” Inag
