Aliases
EFL6; EPLG8; LERK8; Ephrin B3; LIGAND OF EPH-RELATED KINASE 8
Antibody Type
Polyclonal Antibody
Uniprot ID
Swiss-Prot: Q15768
NCBI Gene ID: 1949
Immunogen
Synthesized peptide derived from human Ephrin-B3.
Raised In
Rabbit
Species Reactivity
Human Mouse Rat
Tested Applications
WB IHC Recommended dilution: Western blotting: 1:500~1:3000, Immunohistochemistry: 1:50~1:100,
Background / Function
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons By similarity.Mitsutoshi Nakada, Cancer Res., Sep 2006; 66: 8492 – 8500.Klas Kullander, Genes & Dev., Apr 2001; 15: 877.M. Douglas Benson, PNAS, Jul 2005; 102: 10694 – 10699.Stephanie R. Kadison, J. Neurosci., Aug 2006; 26: 8909 – 8914.
Conjugate
Unconjugated
Storage Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
