Aliases
F-box only protein 3, FBXO3, FBX3
Antibody Type
Polyclonal
Species
Human
Uniprot ID
Q9UK99
Immunogen
Recombinant Human F-box only protein 3 protein (276-376AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA
Background / Function
Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.
Isotype
IgG
Conjugate
Biotin
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
>95%,Protein G purified
Modification
F-box only protein 3
