GLCE Antibody, HRP conjugated

Description

Aliases

Heparan sulfate C5-epimerase, Hsepi, Heparin/heparan sulfate:glucuronic acid C5-epimerase, Heparosan-N-sulfate-glucuronate 5-epimerase, GLCE, KIAA0836

Antibody Type

Polyclonal Antibody

Species

Human

Uniprot ID

O94923

Immunogen

Recombinant human D-glucuronyl C5-epimerase protein (29-617AA)

Raised In

Rabbit

Species Reactivity

Human

Tested Applications

ELISA;Not yet tested in other applications.

Background / Function

Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins.

Isotype

IgG

Conjugate

HRP

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Caprylic Acid Ammonium Sulfate Precipitation purified

Research

Cancer

Literature

[1]”Uncovering a biphasic catalytic mode of C5-epimerase in heparan sulfate biosynthesis.”Sheng J., Xu Y., Dulaney S.B., Huang X., Liu J.J. Biol. Chem. 287:20996-21002(2012) [2]”Using engineered 2-O-sulfotransferase to determine the activity of heparan s

Additional information

Size	50μg, 100μg