Aliases
Guanosine 5′-monophosphate oxidoreductase 2, Guanosine monophosphate reductase 2, GMPR2
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
Q9P2T1
Immunogen
Recombinant human GMP reductase 2 protein (1-366AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation.
Isotype
IgG
Conjugate
Unconjugated
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Modification
GMP reductase 2
Literature
[1]”Cofactor mobility determines reaction outcome in the IMPDH and GMPR (beta-alpha)8 barrel enzymes.” Patton G.C., Stenmark P., Gollapalli D.R., Sevastik R., Kursula P., Flodin S., Schuler H., Swales C.T., Eklund H., Himo F., Nordlund P., Hedstrom L. Nat. Chem. Biol. 7:950-958(2011). [2]”Crystal structure of human guanosine monophosphate reductase 2 (GMPR2) in complex with GMP.” Li J., Wei Z., Zheng M., Gu X., Deng Y., Qiu R., Chen F., Ji C., Gong W., Xie Y., Mao Y. J. Mol. Biol. 355:980-988(2006). [3]”Initial characterization of the human central proteome.” Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011).
