Aliases
Histone acetyltransferase 1; Histone acetyltransferase type B catalytic subunit; EC 2.3.1.48; HAT1;
Antibody Type
Polyclonal Antibody
Uniprot ID
Swiss-Prot: O14929
NCBI Gene ID: 8520
Immunogen
Synthesized peptide derived from Internal of human HAT.
Raised In
Rabbit
Species Reactivity
Human Mouse Rat
Tested Applications
WB Recommended dilution: Western blotting: 1:500~1:3000
Background / Function
Acetylates soluble but not nucleosomal histone H4 at ‘Lys-5’ (H4K5ac) and ‘Lys-12’ (H4K12ac) and, to a lesser extent, acetylates histone H2A at ‘Lys-5’ (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage.Claudia J. Schroder-Adams, Bulletin of Canadian Petroleum Geology, Sep 1997; 45: 356 – 376. Pil-Hoon Park, Am J Physiol Gastrointest Liver Physiol, Dec 2005; 289: G1124 – G1136. Claudia J. Schroeder-Adams, Palaios, Aug 1998; 13: 361 – 375. L. J. Patric
Conjugate
Unconjugated
Storage Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
