Aliases
Histone deacetylase 5, Antigen NY-CO-9, HDAC5, KIAA0600
Antibody Type
Polyclonal
Species
Human
Uniprot ID
Q9UQL6
Immunogen
Recombinant human Histone deacetylase 5 protein (1-100AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA, IHC, IF;Not yet tested in other applications.
Background / Function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Isotype
IgG
Conjugate
Unconjugated
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
>95%,Protein G purified
Modification
Histone deacetylase 5
