Aliases
Putative GTP-binding protein RAY-like, Rab-like protein 4, IFT27, RABL4, RAYL
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
Q9BW83
Immunogen
Recombinant human Intraflagellar transport protein 27 homolog protein (1-186AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6 (PubMed:25443296). Not involved in entry of the BBSome complex into cilium. Prevents aggregation of GTP-free ARL6 (PubMed:25443296). Required for hedgehog signaling. Forms a subcomplex within the IFT complex B with IFT25 (By similarity).
Isotype
IgG
Conjugate
Biotin
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Literature
[1]”The intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3.” Liew G.M., Ye F., Nager A.R., Murphy J.P., Lee J.S., Aguiar M., Breslow D.K., Gygi S.P., Nachury M.V. Dev. Cell 31:265-278(2013). [2]”IFT27, encoding a small GTPase component of IFT particles, is mutated in a consanguineous family with Bardet-Biedl syndrome.” Aldahmesh M.A., Li Y., Alhashem A., Anazi S., Alkuraya H., Hashem M., Awaji A.A., Sogaty S., Alkharashi A., Alzahrani S., Al Hazzaa S.A., Xiong Y., Kong S., Sun Z., Alkuraya F.S. Hum. Mol. Genet. 23:3307-3315(2013). [3]”Initial characterization of the human central proteome.” Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2010).
