Aliases
Insulin-like growth factor I receptor; CD221; IGF1R; kinase IGF1R;
Antibody Type
Polyclonal Antibody
Uniprot ID
Swiss-Prot: P08069
NCBI Protein: NP_000866.1
Immunogen
Peptide sequence around aa.1159~1163 (D-I-Y-E-T) derived from Human IGF-1R .
Raised In
Rabbit
Species Reactivity
Human Mouse Rat
Tested Applications
WB IHC IF Recommended dilution: Predicted MW: 200 95 kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Background / Function
This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.Li S, et al. (1994) J Biol Chem; 269(51). Hernandez-Sanchez C, et al. (1995) J Biol Chem.
Conjugate
Unconjugated
Storage Buffer
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
