Aliases
Mitogen-activated protein kinase kinase kinase 13; EC 2.7.11.25; Mixed lineage kinase; MLK; Leucine zipper-bearing kinase
Antibody Type
Polyclonal Antibody
Uniprot ID
Swiss-Prot: O43283
NCBI Gene ID: 9175
Immunogen
Synthesized peptide derived from internal of human M3K13.
Raised In
Rabbit
Species Reactivity
Human Mouse Rat
Tested Applications
WB Recommended dilution: Western blotting: 1:500~1:3000
Background / Function
Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.Sakuma H., J. Biol. Chem. 272:28622-28629(1997).Schultz S.J., Cell Growth Differ. 4:821-830(1993).Ikeda A., FEBS Lett. 488:190-195(2001).
Conjugate
Unconjugated
Storage Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
