Description
Aliases
C-mer; MERK; MERTK;
Antibody Type
Polyclonal Antibody
Uniprot ID
Swiss-Prot#: Q12866/Q06418;
NCBI Gene#: 10461
Immunogen
Peptide sequence around phosphorylation site of tyrosine 749/681(K-I-Y(p)-S-G) derived from Human MER/SKY .
Raised In
Rabbit
Species Reactivity
Human Mouse Rat
Tested Applications
WB IHC Recommended dilution: Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Background / Function
This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). Graham D.K., Cell Growth Differ. 5:647-657(1994).Gal A., Nat. Genet. 26:270-271(2000).Hillier L.W., Nature 434:724-731(2005).
Conjugate
Unconjugated
Storage Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Modification
Phospho-Tyr749/681
Additional information
| Size | 100μl |
|---|
