Aliases
HGF receptor; receptor; Met proto-oncogene tyrosine kinase; c-met; kinase Met
Antibody Type
Polyclonal Antibody
Uniprot ID
Swiss-Prot: P08581
NCBI Protein: NP_000236.2
Immunogen
Peptide sequence around phosphorylation site of tyrosine 1234 (K-E-Y(p)-Y-S) derived from Human Met.
Raised In
Rabbit
Species Reactivity
Human Mouse Rat
Tested Applications
WB Recommended dilution: Predicted MW: 156kd, Western blotting: 1:500~1:1000,
Background / Function
Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity. Functions in cell proliferation, scattering, morphogenesis and survival.Gherardi E. et al. (2003).Proc Natl Acad Sci U S A. 100(21): 12039-12044. Shiu SH. et al. (2001) Proc Natl Acad Sci U S A. 98(19): 10763-10768. Hughes AL. et al. (2001) Genome Res. 11(5): 771-780.Onuchic LF. et al. (2002) Am J Hum Genet. 70(5): 1305-1317.
Conjugate
Unconjugated
Storage Buffer
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Modification
Phospho-Tyr1234
