Aliases
Melanocortin-2 receptor accessory protein 2, MC2R accessory protein 2, MRAP2, C6orf117
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
Q96G30
Immunogen
Recombinant human Melanocortin-2 receptor accessory protein 2 protein (66-205AA)
Raised In
Rabbit
Species Reactivity
Human,Mouse
Tested Applications
ELISA, IF, WB, IHC;Not yet tested in other applications.
Background / Function
Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP. May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo.
Isotype
IgG
Conjugate
Unconjugated
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
>95%,Protein G purified
