Aliases
Cleavage and polyadenylation specificity factor subunit 5, Cleavage and polyadenylation specificity factor 25 kDa subunit, CFIm25, CPSF 25 kDa subunit, Nucleoside diphosphate-linked moiety X motif 21, Nudix motif 21, Pre-mRNA cleavage factor Im 25 kDa subunit, NUDT21, CFIM25, CPSF25, CPSF5
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
O43809
Immunogen
Recombinant human Cleavage and polyadenylation specificity factor subunit 5 protein (2-227AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA, WB, IHC, IF;Recommended dilution:WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200
Background / Function
Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3′-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3′-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5′-UGUA-3′ elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export.
Isotype
IgG
Conjugate
Unconjugated
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
>95%,Protein G purified
