Aliases
2′-5′-oligoadenylate synthase 3, (2-5′)oligo(A) synthase 3, 2-5A synthase 3, p100 OAS, p100OAS, OAS3, P/OKcl.4
Antibody Type
Polyclonal
Species
Human
Uniprot ID
Q9Y6K5
Immunogen
Recombinant Human 2′-5′-oligoadenylate synthase 3 protein (424-565AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA
Background / Function
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2′-5′-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV).
Isotype
IgG
Conjugate
Biotin
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
>95%,Protein G purified
Modification
2′-5′-oligoadenylate synthase 3
