Aliases
t-plasminogen activator, PLAT
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
P00750
Immunogen
Recombinant human Tissue-type plasminogen activator protein (36-556AA)
Raised In
Rabbit
Species Reactivity
Human,mouse
Tested Applications
ELISA, WB, IHC;Recommended dilution:IHC:1:20-1:200
Background / Function
Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.
Isotype
IgG
Conjugate
Unconjugated
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Literature
[1]The human tissue plasminogen activator gene. Friezner Degen S.J., Rajput B., Reich E. J. Biol. Chem. 261:6972-6985(1986). [2]A brain-type plasminogen activator. Dou D. Submitted (APR-2000). [3]Lysine 156 promotes the anomalous proenzyme activity of tPA: X-ray crystal structure of single-chain human tPA. Renatus M., Engh R.A., Stubbs M.T., Huber R., Fischer S., Kohnert U., Bode W. EMBO J. 16:4797-4805(1997).
