Description
General Description
PMPI is p-maleimidophenyl isocyanate, a maleimide-and-isocyanate crosslinker for attaching compounds to sulfhydryl groups of cysteines after conjugating the linker to hydroxyl groups on a molecule by urethane (carbamate) bonds. The Maleimide group of PMPI reacts with sulfhydryl groups to form stable thioether linkages and Isocyanate reacts with non-aqueous hydroxyl groups to form carbamate linkage. It is an excellent tool for conjugating hydroxyl-containing compounds such as steroids and vitamins, but targets and reaction solutions must not contain primary amines.
Molecular Formula: C11H6N2O3
Molecular weight: 214.1
CAS Number: 123457-83-0
Spacer arm: 8.7Å
Melting Point: 120-125 °C
Storage Temperature: 2-8°C
Features of PMPI:
1. Reactive groups – Maleimide and Isocyante
2. Reactive towards – Sulfhydryl and Hydroxyl groups
3. Spacer Arm – Short spacer arm (8.7 Å)
4. A novel heterobifunctional crosslinker sulfhydryl-to-hydroxyl coupling with an aromatic spacer arm (non-cleavable)
5. Excellent tool for the preparation of conjugates of hydroxyl containing compounds such as steroids and vitamins
Additional information
| Size | 50 mg |
|---|
