Aliases
Phosphatidylinositol 3, 4, 5-trisphosphate-dependent Rac exchanger 2 proteinP-Rex2PtdIns(3, 4, 5)-dependent Rac exchanger 2, DEP domain-containing protein 2, PREX2, DEPDC2
Antibody Type
Polyclonal
Species
Human
Uniprot ID
Q70Z35
Immunogen
Recombinant human Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein (1417-1592AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.
Isotype
IgG
Conjugate
FITC
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
>95%,Protein G purified
Modification
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein
