Aliases
tumor necrosis factor receptor superfamily, member 4
Antibody Type
Polyclonal Antibody
Uniprot ID
P43489
Immunogen
Synthetic peptide of human TNFRSF4
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA: 1:1000-1:2000; WB:1:200-1:1000
Background / Function
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.
Isotype
IgG
Conjugate
Unconjugated
Storage Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Antigen affinity purification
