Description
Aliases
RNA 3′-terminal phosphate cyclase (EC:6.5.1.4), RNA cyclase, RNA-3′-phosphate cyclase, RTCA, RPC, RPC1, RTC1, RTCD1, RNA terminal phosphate cyclase domain-containing protein 1, RTC domain-containing protein 1
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
O00442
Immunogen
Recombinant human RNA 3′-terminal phosphate cyclase protein (167-379AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Catalyzes the conversion of 3′-phosphate to a 2′,3′-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3’P to produce RNA-N3’PP5’A; (C) and attack of the adjacent 2′-hydroxyl on the 3′-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
Isotype
IgG
Conjugate
Biotin
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Additional information
| Size | 50μg, 100μg |
|---|
