Aliases
N-lysine methyltransferase SMYD2, HSKM-B, Histone methyltransferase SMYD2, Lysine N-methyltransferase 3C, SET and MYND domain-containing p, SMYD2, KMT3C
Antibody Type
Polyclonal
Species
Human
Uniprot ID
Q9NRG4
Immunogen
Recombinant human N-lysine methyltransferase SMYD2 protein (115-272AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA, IHC, IF;Not yet tested in other applications.
Background / Function
Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 ‘Lys-4’ (H3K4me) and dimethylates histone H3 ‘Lys-36’ (H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates ‘Lys-370’ of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at ‘Lys-860’.
Isotype
IgG
Conjugate
Unconjugated
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
>95%,Protein G purified
Modification
N-lysine methyltransferase SMYD2
