Description
Aliases
Sorcin, 22 kDa protein, CP-22, CP22, V19, SRI
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
P30626
Immunogen
Recombinant human Sorcin protein (1-198AA)
Raised In
Rabbit
Species Reactivity
Human,Mouse
Tested Applications
ELISA, WB, IHC;Recommended dilution:WB:1:200-1000, IHC:1:20-1:200
Background / Function
Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.
Isotype
IgG
Conjugate
Unconjugated
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Antigen Affinity Purified
Literature
[1]Molecular basis for the impaired function of the natural F112L sorcin mutant: X-ray crystal structure, calcium affinity, and interaction with annexin VII and the ryanodine receptor.”Franceschini S., Ilari A., Verzili D., Zamparelli C., Antaramian A., Rueda A., Valdivia H.H., Chiancone E., Colotti G.FASEB J. 22:295-306(2008). [2]Crystal structure of calcium-free human sorcin: a member of the penta-EF-hand protein family.” Xie X., Dwyer M.D., Swenson L., Parker M.H., Botfield M.C.Protein Sci. 10:2419-2425(2001). [3]Initial characterization of the human central proteome.”Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011).Additional information
| Size | 50μl, 100μl |
|---|
