Aliases
SCL; TAL1; TCL5;
Antibody Type
Polyclonal Antibody
Uniprot ID
Swiss-Prot#: P17542;
NCBI Gene#: 6886;
N
Immunogen
Peptide sequence around phosphorylation site of Serine 122(Q-L-S(p)-P-P) derived from Human TAL-1.
Raised In
Rabbit
Species Reactivity
Human Rat
Tested Applications
WB Recommended dilution: Western blotting: 1:500~1:1000
Background / Function
TAL-1 is a basic helix-loop-helix transcription. Regulates differentiation and survival during hemopoiesis. Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of eryhtroid differentiation. Mutations are associated with T-cell leukemia and melanoma. Binds to the LIM domain containing protein Rhombotin-2. Aplan P.D., Mol. Cell. Biol. 10:6426-6435(1990).Gregory S.G., Nature 441:315-321(2006).Chen Q., J. Exp. Med. 172:1403-1408(1990).
Conjugate
Unconjugated
Storage Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Modification
Phospho-Ser122
