Description
Aliases
Tentoxylysin, Tetanus toxin chain L, Tetanus toxin chain H, CTC_p60, tetX
Antibody Type
Polyclonal Antibody
Species
Clostridium tetani
Uniprot ID
P04958
Immunogen
Recombinant Clostridium tetani Tetanus toxin protein (123-573AA)
Raised In
Rabbit
Species Reactivity
Clostridium tetani
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the ’76-Gln-|-Phe-77′ bond of synaptobrevin-2.
Isotype
IgG
Conjugate
HRP
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Modification
Tetanus toxin
Literature
[1]”Structure of the receptor binding fragment HC of tetanus neurotoxin.” Umland T.C., Wingert L.M., Swaminathan S., Furey W.F. Jr., Schmidt J.J., Sax M. Nat. Struct. Biol. 4:788-792(1997). [2]”Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin.” Schiavo G., Benfenati F., Poulain B., Rossetto O., de Laureto P.P., Dasgupta B.R., Montecucco C. Nature 359:832-835(1992). [3]”Tetanus toxin is a zinc protein and its inhibition of neurotransmitter release and protease activity depend on zinc.” Schiavo G., Poulain B., Rossetto O., Benfenati F., Tauc L., Montecucco C. EMBO J. 11:3577-3583(1992).Additional information
| Size | 50μg, 100μg |
|---|
