Aliases
Transducin-like enhancer protein 2; ESG2;
Antibody Type
Polyclonal Antibody
Uniprot ID
Swiss-Prot: Q04725
NCBI Gene ID: 7089
Immunogen
Synthesized peptide derived from internal of human TLE2.
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
WB Recommended dilution: Western blotting: 1:500~1:3000
Background / Function
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES By similarity.Stifani S., Nat. Genet. 2:119-127(1992).Grimwood J., Nature 428:529-535(2004).Grbavec D., Eur. J. Biochem. 258:339-349(1998).
Conjugate
Unconjugated
Storage Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
