Aliases
RNA polymerase I termination factor, Transcription termination factor I, TTF1
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
Q15361
Immunogen
Recombinant human Transcription termination factor 1 protein (11-242AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity.
Isotype
IgG
Conjugate
FITC
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Modification
Transcription termination factor 1 protein
Research
Transcription
Literature
[1] “Molecular evolution of mammalian ribosomal gene terminator sequences and the transcription termination factor TTF-1.”Evers R., Grummt I.Proc. Natl. Acad. Sci. U.S.A. 92:5827-5831(1995) [2] “DNA sequence and analysis of human chromosome 9.”Humphray
