TW-37

Description

TW-37 is a potent inhibitor of BCL-2, which attenuates BCL-2 activation and inhibits multiple BCL-2 family members including BCL-XL and MCL-1. It binds to the BCL-2 homology domain 3 (BH3) groove of BCL-2, preventing the heterodimerization of proapoptotic proteins such as Bid, Bim, and Bad) with BCL-2 and subsequently allowing them to induce apoptosis.

CAS No.: 877877-35-5

Molecular Formula: C33H35NO6S

MW: 573.7

Purity: ≥95%

Solubility: DMSO >100mM

Storage Temp.: -20°C

Handling: Protect from moisture

Additional information