Aliases
Polymerase cofactor VP35, VP35
Antibody Type
Polyclonal Antibody
Species
Reston ebolavirus
Uniprot ID
Q91DE0
Immunogen
Recombinant Reston ebolavirus Polymerase cofactor VP35 protein (1-329AA)
Raised In
Rabbit
Species Reactivity
Reston ebolavirus
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. This blockage is produced through the interaction with and inhibition host IKBKE and TBK1 producing a strong inhibition of the phosphorylation and activation of IRF3. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.
Isotype
IgG
Conjugate
FITC
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
>95%,Protein G purified
