Aliases
UNQ659/PRO1291, B7H4, VTCN1, B7h.5, Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
Q7Z7D3
Immunogen
Recombinant human V-set domain-containing T-cell activation inhibitor 1 protein (26-258AA)
Raised In
Rabbit
Species Reactivity
human
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
Isotype
IgG
Conjugate
HRP
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Research
Immunology
Literature
[1] “B7-H4, a molecule of the B7 family, negatively regulates T cell immunity.”Sica G.L., Choi I.-H., Zhu G., Tamada K., Wang S.-D., Tamura H., Chapoval A.I., Flies D.B., Bajorath J., Chen L.Immunity 18:849-861(2003) [2] “B7x: a widely expressed B7 fami
