Description
Aliases
XWnt-8, wnt8
Antibody Type
Polyclonal Antibody
Species
Xenopus laevis
Uniprot ID
P28026
Immunogen
Recombinant Xenopus laevis Protein Wnt-8 protein (23-358AA)
Raised In
Rabbit
Species Reactivity
Xenopus laevis
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in ventral mesodermal patterning during embryogenesis. Mimics Nieuwkoop center activity. Causes dorsal mesodermal differentiation of animal cap ectoderm when coexpressed with noggin and nuclear, sequence-specific DNA-binding protein xBra. None of these molecules causes dorsal mesoderm formation when expressed alone.
Isotype
IgG
Conjugate
HRP
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Literature
[1]”Structural basis of Wnt recognition by Frizzled.”Janda C.Y., Waghray D., Levin A.M., Thomas C., Garcia K.C.Science 337:59-64(2011). [2]”Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation.” Zhang X., Abreu J.G., Yokota C., Macdonald B.T., Singh S., Coburn K.L., Cheong S.M., Zhang M.M., Ye Q.Z., Hang H.C., Steen H., He X.Cell 149:1565-1577(2011). [3]”The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals.”Piccolo S., Agius E., Leyns L., Bhattacharyya S., Grunz H., Bouwmeester T., De Robertis E.M.Nature 397:707-710(1998).Additional information
| Size | 50μg, 100μg |
|---|
