3,3′-Di-Indole Methane

CAS #

1968-05-4

Concentration

98.00%

Description

3,3′-Di-Indole Methane is an acid-catalyzed reaction product of a phytochemical naturally found in Brassicaceae, indole-3-carbinol. It functions as an antitumor agent. This derivative can both directly stimulate apoptosis at relatively high concentrations and sensitize TRAIL-induced apoptosis in human cancer cells. DIM induces a G1 cell cycle arrest in human breast cancer MCF-7 cells by a mechanism that includes increased expression of p21. DIM is a strong mitochondrial H+-ATPase inhibitor.

Keywords

3,3′-Bisindolylmethane, DIM, Arundine, HB 236