Melatonin

CAS #

73-31-4

Concentration

98.00%

Description

Melatonin is a hormone responsible for mediating photoperiodicity in mammals. It inhibits cerebellar nitric oxide synthetase, and is a peroxynitrite scavenger. Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell death of cancer cells. It inhibits proliferation/metastasis of breast cancer cells by inhibiting estrogen receptor action. Melatonin is characterized with variety of properties such as antioxidant, autocoid, paracoid and hormonal properties, as well as anti- inflammatory and anti-apoptotic properties. Melatonin is implicated in the regulation of seasonal reproduction, energy metabolism and thermoregulation in mammals. Melatonin also plays a vital role in the lessening of neonatal hypoxia–ischemia (HI) induced endoplasmic reticulum (ER) stress and conserves sirtuin 1( SIRT-1) expression.

Keywords

N-Acetyl-5-methoxytryptamine