DPDPB (1,4-Di [3’-(2’-pyridyldithio)propionamido] Butane)

General Description

DPDPB is a sulfhydryl reactive homobifunctional reagent with a spacer arm of 19.9 Å. It reacts with sulfhydryls to form a mixed disulfide, which can be readily cleaved in presence of a reducing agent. It functions via cysteine crosslinking and can be used to study protein structural analysis, protein modification, proteomics and homobifunctional cross-linking reagents.

CAS Number:             141647-62-3

Molecular Weight:    482.71

Molecular Formula:  C₂₀H₂₆N₄O₂S₄

Purity:                          >90% by HPLC

Reference(s):

G.N. Zecherle et al. J. Biol. Chem. 267, 5889, (1992)