UCP1 Antibody

Aliases UCP 1, Solute carrier family 25 member 7, Thermogenin, UCP1, SLC25A7, UCP Antibody Type Polyclonal Antibody Species Human Uniprot ID P25874 Immunogen Recombinant human Mitochondrial brown fat uncoupling protein 1 protein (1-307AA) Raised In Rabbit Species Reactivity Human,Mouse Tested Applications ELISA, WB, IHC;Recommended dilution:WB:1:500-5000, IHC:1:20-1:200 Background / Function UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. Isotype IgG Conjugate Unconjugated Storage Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form Liquid Storage Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze. Purity Antigen Affinity Purified Literature [1]”Uncoupling protein 1 and 3 polymorphisms are associated with waist-to-hip ratio.”Herrmann S.M., Wang J.G., Staessen J.A., Kertmen E., Schmidt-Petersen K., Zidek W., Paul M., Brand E.J. Mol. Med. 81:327-332(2002). [2]”A polymorphism in the 5′ untranslated region and a Met229–>Leu variant in exon 5 of the human UCP1 gene are associated with susceptibility to type II diabetes mellitus.”Mori H., Okazawa H., Iwamoto K., Maeda E., Hashiramoto M., Kasuga M.Diabetologia 44:373-376(2000). [3]”Detection of brown adipose tissue uncoupling protein mRNA in adult patients by a human genomic probe.”Bouillaud F., Villarroya F., Hentz E., Raimbault S., Cassard A.M., Ricquier D.Clin. Sci. 75:21-27(1987).