Curcumin

Curcumin, a tyrosinase inhibitor, exists as a pigment in the natural/dietary agent Curcuma longa L (turmeric). Also referred to as diferuloyl methane, it is a symmetric molecule with a 7-carbon linker connecting two o-methoxy phenolic groups containing aromatic rings. It is synthesized by Pabon′s reaction using vanillin and acetyl acetone in the presence of boric oxide.

CAS No.:                      458-37-7

Molecular Formula:   C₂₁H₂₀O₆

MW:                              368.38

Purity:                           ≥98%

Solubility:                    DMSO (25 mg/ml) or EtOH (10 mg/ml)

Storage Temp.:           -20°C

Handling:                     Protect from air and light

Applications:

• as a supplement to evaluate its anti-carcinogenic and anti-apoptotic effect on cancer cells and cardiomyocytes
• to test its anti-inflammatory effect in human promyelocytic leukemia cell line, the HL-60
• to evaluate its attenuating effect on amyloidαβ pathology