SOST Antibody

Aliases SOST Antibody Type Polyclonal Antibody Species Human Uniprot ID Q9BQB4 Immunogen Recombinant human Sclerostin protein (24-213AA) Raised In Rabbit Species Reactivity Human Tested Applications ELISA, WB, IHC ;Recommended dilution:WB:1:500-2000, IHC:1:20-1:200 Background / Function Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. Isotype IgG Conjugate Unconjugated Storage Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form Liquid Storage Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze. Purity Antigen Affinity Purified Literature [1]”Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein.”Brunkow M.E., Gardner J.C., Van Ness J., Paeper B.W., Kovacevich B.R., Proll S., Skonier J.E., Zhao L., Sabo P.J., Fu Y.H., Alisch R.S., Gillett L., Colbert T., Tacconi P., Galas D., Hamersma H., Beighton P., Mulligan J.T. Am. J. Hum. Genet. 68:577-589(2001). [2]”DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.”Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. Nusbaum C. Nature 440:1045-1049(2006). [3]”The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”The MGC Project TeamGenome Res. 14:2121-2127(2004).